Description

Trifluoroacetic Acid (TFA) is a highly versatile and potent fluorinated organic acid. Its unique combination of strong acidity and excellent solvating properties makes it a critical reagent and solvent in advanced chemical synthesis and purification processes. This compound is essential for industries requiring high-performance fluorination chemistry, including pharmaceutical manufacturing, agrochemical development, and materials science.

Application

• Pharmaceutical Synthesis: A key reagent and protecting group removal agent (e.g., for Boc deprotection) in the production of active pharmaceutical ingredients (APIs) and peptides.
• HPLC Mobile Phase Component: Used as an ion-pairing agent in reverse-phase high-performance liquid chromatography (HPLC) for the separation and analysis of peptides, proteins, and other biomolecules.
• Organic Solvent & Catalyst: Serves as a powerful solvent for resins and a catalyst in various organic reactions, including esterifications and rearrangements.
• Chemical Intermediate: Employed in the synthesis of fluorinated compounds, dyes, and specialty chemicals where the introduction of the trifluoromethyl group is required.
• Polymer & Materials Science: Used in the production and processing of specialty polymers and as an etching agent in the electronics industry.
• Analytical Chemistry: Functions as a derivatization agent and volatile acid in mass spectrometry and other analytical techniques.

Basic Information

Item	Detail
Product Name	Trifluoroacetic Acid
CAS No.	2055839-78-4
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; TFA; Perfluoroacetic Acid; 2,2,2-Trifluoroacetic Acid; Acetic Acid, Trifluoro-; Trifluoroacetic Acid Anhydride (common misnomer); CF3COOH
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive applications like pharmaceutical synthesis and analytical chromatography. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile and hygroscopic nature, containers should be kept tightly sealed when not in use to prevent moisture absorption and evaporation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
Residue on Evaporation	≤ 0.005%
Chloride (Cl)	≤ 10 ppm
Sulfate (SO4)	≤ 10 ppm
Heavy Metals (as Pb)	≤ 5 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.