Description

(R)-tert-Butyl 4-(Aminomethyl)-3,3-Difluoropiperidine-1-Carboxylate is a high-purity, chiral piperidine derivative featuring both a protected amine and difluoromethylene groups. This compound serves as a critical advanced pharmaceutical intermediate (API) for the synthesis of novel bioactive molecules, particularly in drug discovery programs targeting the central nervous system and metabolic diseases. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality building blocks for constructing complex drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a linker or component in the design of bifunctional molecules for targeted protein degradation.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship exploration by introducing a rigid, fluorinated piperidine scaffold into lead compounds.
• Process Chemistry & Scale-up: Serves as a validated starting material for the GMP-compliant synthesis of clinical trial materials.
• Agrochemical Research: Potential intermediate for developing novel crop protection agents with enhanced metabolic stability.
• Fluorinated Compound Library Synthesis: A valuable building block for creating focused screening libraries to discover new fluorinated drug candidates.

Basic Information

Product Name	(R)-tert-Butyl 4-(Aminomethyl)-3,3-Difluoropiperidine-1-Carboxylate
CAS No.	2055043-54-2
Molecular Formula	C11H20F2N2O2
Molecular Weight	250.29 g/mol
Synonyms	1-Boc-4-(aminomethyl)-3,3-difluoropiperidine, (R)-enantiomer; tert-Butyl (3R)-4-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate; (R)-1-N-Boc-4-(aminomethyl)-3,3-difluoropiperidine; 3,3-Difluoro-4-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester; (R)-4-(Aminomethyl)-3,3-difluoro-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; BOC-(R)-4-(Aminomethyl)-3,3-difluoropiperidine; (R)-tert-Butyl 4-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of (R)-tert-Butyl 4-(Aminomethyl)-3,3-Difluoropiperidine-1-Carboxylate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and LC-MS for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications. Our commitment to consistent high purity and reliable supply supports critical pharmaceutical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Optimal storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.