Description

Bromoacetamido-Peg8-T-Butyl Ester is a specialized bifunctional polyethylene glycol (PEG) derivative featuring a reactive bromoacetamide group and a protected carboxylic acid. This compound is a critical building block for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined bioconjugates. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications such as antibody-drug conjugate (ADC) development, peptide modification, and the functionalization of nanoparticles and surfaces.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: Used to introduce a hydrophilic PEG spacer with a reactive handle onto peptides, proteins, or small molecules to improve solubility, stability, and pharmacokinetic profiles.
• Bioconjugation & Protein Labeling: The bromoacetamide group selectively reacts with thiols (cysteine residues), enabling controlled, site-specific labeling of proteins and antibodies with dyes, drugs, or other functional groups.
• Surface Functionalization: Employed to modify materials (e.g., gold nanoparticles, sensor chips, resins) with a PEG layer terminated with a reactive group for subsequent biomolecule immobilization.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a versatile building block for introducing PEG chains and conjugation sites during peptide synthesis.
• Crosslinking Agent: Facilitates the covalent crosslinking of thiol-containing molecules in biochemical and material science applications.
• Prodrug Development: Utilized in the design of prodrugs where the active molecule is attached via a cleavable PEG-based linker.
• Research & Development: A valuable tool in academic and industrial R&D for exploring novel drug delivery systems and bioconjugation strategies.

Basic Information

Product Name	Bromoacetamido-Peg8-T-Butyl Ester
CAS No.	2055041-16-0
Molecular Formula	C29H56BrN2O12
Molecular Weight	689.67 g/mol
Synonyms	2-Bromo-N-(2,5,8,11,14,17,20,23-octaoxapentacos-25-yl)acetamide; Bromoacetamido-PEG8-t-butyl ester; t-Butyl 25-(2-bromoacetamido)-3,6,9,12,15,18,21,24-octaoxapentacosanoate; Bromoacetamide-PEG8-acid t-butyl ester; α-Bromoacetamido-ω-carboxylic acid (t-butyl ester), PEG8; 8-Amino-3,6,9,12,15,18,21,24-octaoxahexacosanoic acid, N-(bromoacetyl)-, 1,1-dimethylethyl ester; Bromoacetyl-PEG8-NH-t-butyl ester; PEG8-Bromoacetamide-t-butyl ester
EINECS	Contact for details

Quality Control

Our Bromoacetamido-Peg8-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical R&D and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.