Description

Acid-Peg5-Tempo CAS NO 2055040-79-2 is a specialized bifunctional PEG derivative, combining a carboxylic acid group with a stable nitroxyl radical (TEMPO) via a pentaethylene glycol (PEG5) spacer. This molecular architecture is engineered to serve as a versatile linker and mediator in advanced synthesis and material science. It is particularly valuable for researchers and manufacturers in the pharmaceutical, bioconjugation, and polymer chemistry sectors who require precise, water-soluble, and functional intermediates for creating smart materials, drug delivery systems, or as catalysts in selective oxidations.

Application

• Bioconjugation & Drug Delivery: Acts as a heterobifunctional crosslinker for attaching therapeutic molecules (e.g., drugs, peptides) to carriers like antibodies, proteins, or nanoparticles, leveraging the carboxylic acid for amide bond formation and the PEG spacer for enhanced solubility and reduced immunogenicity.
• Polymer Functionalization & Grafting: Used to introduce stable radical or carboxylic acid sites onto polymer backbones for creating functional materials, facilitating further chemical modifications, or initiating controlled radical polymerization.
• Catalysis (Selective Oxidation): The TEMPO moiety can function as a catalyst or co-catalyst in the selective oxidation of primary alcohols to aldehydes, with the PEG chain improving solubility in various reaction media.
• Surface Modification: Employed to modify the surface of materials (e.g., gold nanoparticles, silica, graphene oxide) by anchoring via the acid group, imparting radical character or creating a hydrophilic PEG layer for improved biocompatibility.
• Spin Labeling in Biochemistry: Serves as a spin label in Electron Paramagnetic Resonance (EPR) spectroscopy studies to probe protein dynamics, structure, and interactions, with the PEG linker providing flexibility.
• Intermediate for Advanced Materials: A key building block for synthesizing more complex functional molecules, such as stimuli-responsive polymers or novel ligands for metal-organic frameworks (MOFs).

Basic Information

Product Name	Acid-Peg5-Tempo
CAS No.	2055040-79-2
Molecular Formula	C26H50N2O10
Molecular Weight	550.70 g/mol
Synonyms	5-((1-Oxy-2,2,6,6-tetramethylpiperidin-4-yl)oxy)-5-oxopentanoic acid PEG derivative; 4-((2,2,6,6-Tetramethylpiperidin-1-yl)oxy)-4-oxobutanoic acid PEG5 ester; TEMPO-PEG5-acid; Carboxy-PEG5-TEMPO; 2,2,6,6-Tetramethyl-1-piperidinyloxy, PEG5 carboxylic acid derivative; 4-Carboxy-TEMPO-PEG5; Acid-terminated PEGylated TEMPO; Heterobifunctional PEG-TEMPO linker
EINECS	Contact for details

Quality Control

Our Acid-Peg5-Tempo is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, NMR (1H, 13C) for structural confirmation, and mass spectrometry to ensure identity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key specifications. For research and development requiring specific grades (e.g., bioconjugation grade), please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by titration or NMR)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.