Description

Propargyl-Peg10-Acid is a heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a carboxylic acid group. This compound is a critical building block in bioconjugation and click chemistry, enabling the precise and efficient modification of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in the fields of pharmaceuticals, diagnostics, and advanced material science who require reliable, high-purity linkers for creating targeted drug delivery systems, diagnostic probes, and functionalized nanomaterials.

Application

• Bioconjugation and Click Chemistry: Serves as a key linker for attaching drugs, dyes, or targeting ligands to antibodies, proteins, or nanoparticles via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted reactions.
• PEGylation Reagent: Used to introduce hydrophilic PEG chains onto therapeutic peptides, proteins, or small molecule drugs to improve solubility, prolong circulation half-life, and reduce immunogenicity.
• Surface Functionalization: Enables the modification of biosensor surfaces, microarray slides, and other solid supports with carboxylic acid groups for subsequent covalent immobilization of biomolecules.
• Polymer Synthesis: Acts as a functional monomer or cross-linker in the synthesis of smart hydrogels, micelles, and other advanced polymeric materials with tailored properties.
• Diagnostic Probe Development: Facilitates the creation of fluorescent or radioactive probes for in vitro and in vivo imaging applications.
• ADC (Antibody-Drug Conjugate) Linker: Provides a cleavable or non-cleavable spacer between the antibody and the cytotoxic payload in ADC development.

Basic Information

Product Name	Propargyl-Peg10-Acid
CAS No.	2055022-18-7
Molecular Formula	C27H50O13
Molecular Weight	582.68 g/mol
Synonyms	Propargyl-PEG10-acid; Propargyl-PEG10-COOH; α-Propargyl-ω-carboxy-poly(ethylene glycol); 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacont-30-yn-1-oic acid; Propargyl-PEG10-acetic acid; Propargyl-PEG10-Propionic Acid (common naming variant); Alkyne-PEG10-Acid; Propargyl terminated PEG carboxylic acid (MW ~600)
EINECS	Contact for details

Quality Control

Our Propargyl-Peg10-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) detailing identity, purity, and functional group integrity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay	≥ 90% (for both propargyl and acid)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.