Description

Methyl 4-Hydroxypiperidine-3-Carboxylate Hydrochloride is a high-purity, pharmaceutically relevant piperidine derivative, offered as a stable hydrochloride salt. This compound serves as a critical chiral building block and synthetic intermediate for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the synthesis of complex molecules targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly in neuroscience and oncology research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a starting material or advanced intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized as a scaffold or chiral auxiliary for constructing complex, enantiomerically pure molecules.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Academic & Contract Research: Employed in academic laboratories and by contract research organizations (CROs) for exploratory synthetic projects.

Basic Information

Product Name	Methyl 4-Hydroxypiperidine-3-Carboxylate Hydrochloride
CAS No.	2044704-66-5
Molecular Formula	C8H15NO3 • HCl
Molecular Weight	209.67 g/mol (Free base: 173.21 g/mol)
Synonyms	Methyl 4-hydroxypiperidine-3-carboxylate hydrochloride; 4-Hydroxypiperidine-3-carboxylic acid methyl ester hydrochloride; 3-Piperidinecarboxylic acid, 4-hydroxy-, methyl ester, hydrochloride; Methyl 4-hydroxy-3-piperidinecarboxylate hydrochloride; 4-Hydroxy-3-piperidinecarboxylic acid methyl ester HCl
EINECS	Contact for details

Quality Control

Our Methyl 4-Hydroxypiperidine-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for pharmaceutical R&D and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.