Description

(2S)-2-Methyl-1Lambda6-Thiomorpholine-1,1-Dione Hydrochloride is a high-purity chiral sulfonamide derivative, serving as a critical advanced pharmaceutical intermediate for modern drug discovery and development. Its value lies in its defined stereochemistry and functionalized thiomorpholine scaffold, enabling the synthesis of novel bioactive molecules with potential therapeutic applications. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on creating new active pharmaceutical ingredients (APIs), particularly in areas requiring complex heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting the central nervous system (CNS) and other therapeutic areas.
• Chiral Synthesis: Utilized in asymmetric synthesis and medicinal chemistry programs to introduce the (2S)-methyl-thiomorpholine sulfone moiety into target molecules.
• Protease Inhibitor Research: Serves as a precursor or core structure for developing inhibitors of specific enzymes, such as cysteine proteases.
• Ligand and Catalyst Development: Used in the research and development of chiral ligands for catalysis or as a scaffold for metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	(2S)-2-Methyl-1Lambda6-Thiomorpholine-1,1-Dione Hydrochloride
CAS No.	2043769-78-2
Molecular Formula	C5H10ClNO2S
Molecular Weight	183.66 g/mol
Synonyms	(2S)-2-Methylthiomorpholine 1,1-Dioxide Hydrochloride; (S)-2-Methylthiomorpholine 1,1-Dioxide Hydrochloride; (2S)-2-Methyl-1λ⁶-thiomorpholine-1,1-dione hydrochloride; (S)-2-Methyl-1,1-dioxothiomorpholine Hydrochloride; (2S)-2-Methyl-1,1-dioxo-thiomorpholinium Chloride; (S)-2-Methylthiomorpholine Sulfone Hydrochloride; Thiomorpholine-1,1-dioxide, 2-methyl-, hydrochloride, (2S)-; 2043769-78-2
EINECS	Contact for details

Quality Control

Our (2S)-2-Methyl-1Lambda6-Thiomorpholine-1,1-Dione Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding research and pre-clinical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.