Description

Morpholine, 2-Methyl-3-(Trifluoromethyl)-,(2S,3S)- is a high-purity, chiral morpholine derivative distinguished by its trifluoromethyl group and defined stereochemistry. This compound is a critical advanced pharmaceutical intermediate (API intermediate) valued for its role in constructing complex bioactive molecules. It is essential for research and development chemists in the pharmaceutical and agrochemical sectors who require enantiomerically pure building blocks for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where the trifluoromethyl group and specific stereochemistry enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with unique surface properties or fluorine-containing materials.
• Academic & Industrial R&D: A valuable building block for medicinal chemistry programs and process research in both university laboratories and corporate R&D centers.

Basic Information

Product Name	Morpholine, 2-Methyl-3-(Trifluoromethyl)-,(2S,3S)-
CAS No.	2031242-13-2
Molecular Formula	C7H10F3NO
Molecular Weight	181.16 g/mol
Synonyms	(2S,3S)-2-Methyl-3-(trifluoromethyl)morpholine; (3S,4S)-4-Methyl-3-(trifluoromethyl)morpholine; (2S,3S)-2-Methyl-3-trifluoromethylmorpholine; 2-Methyl-3-(trifluoromethyl)morpholine, (2S,3S)-; (2S,3S)-2-Methyl-3-(trifluoromethyl)-tetrahydro-1,4-oxazine; Enantiomerically pure trifluoromethyl morpholine
EINECS	Contact for details

Quality Control

Our (2S,3S)-2-Methyl-3-(trifluoromethyl)morpholine is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/GC), chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.