Description

Acid-Peg4-Mono-Methyl Ester CAS NO 2028284-75-3 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal carboxylic acid group and a methyl ether terminus. This bifunctional structure is critical for creating stable, water-soluble linkers in bioconjugation and pharmaceutical formulation. It is an essential building block for researchers and manufacturers in the life sciences sector who require precise and reliable PEGylation reagents.

Application

• Bioconjugation Linker: Used to covalently attach therapeutic molecules (e.g., peptides, proteins, antibodies) to other entities like drugs, dyes, or surfaces, improving solubility and pharmacokinetics.
• Pharmaceutical Intermediate: Serves as a key reagent in the synthesis of prodrugs and advanced drug delivery systems, such as polymer-drug conjugates.
• Surface Modification: Employed to functionalize nanoparticles, quantum dots, and diagnostic assay substrates with carboxylic acid groups for subsequent coupling.
• Cross-linking Agent: Acts as a hydrophilic spacer in the preparation of hydrogels and biomaterials for tissue engineering and controlled release applications.
• Polymer Chemistry: A versatile monomer or macromonomer for synthesizing functional, biocompatible copolymers with tailored properties.

Basic Information

Product Name	Acid-Peg4-Mono-Methyl Ester
CAS No.	2028284-75-3
Molecular Formula	C14H28O8
Molecular Weight	324.37 g/mol
Synonyms	mPEG4-acid; mPEG4-COOH; 2,5,8,11-Tetraoxatetradecanedioic acid, 14-methyl-; 3,6,9,12-Tetraoxatetradecanedioic acid, 14-methyl-; Methyl-PEG4-acid; HOOC-PEG4-OCH3; 4,7,10,13-Tetraoxahexadecanedioic acid, 16-methyl-; Carboxy-PEG4-methyl ether
EINECS	Contact for details

Quality Control

Every batch of Acid-Peg4-Mono-Methyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Acid Value (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.