Description

2-[4-(4-Chloro-2-Fluorophenyl)-1-Piperazinyl]Aniline is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is primarily sought after by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antipsychotic and neuroleptic drug candidates targeting dopamine and serotonin receptors.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemists exploring structure-activity relationships (SAR) in new therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step manufacturing process of complex, high-value APIs for clinical trials and commercial production.
• Biochemical Research: Employed in the study of receptor-ligand interactions and the development of biochemical assay tools and probes.
• Fine Chemical Manufacturing: Supplied to contract manufacturing organizations (CMOs) and CDMOs for custom synthesis projects under GMP guidelines.

Basic Information

Product Name	2-[4-(4-Chloro-2-Fluorophenyl)-1-Piperazinyl]Aniline
CAS No.	2006277-40-1
Molecular Formula	C16H17ClFN3
Molecular Weight	305.78 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)-4-(2-aminophenyl)piperazine; 2-[4-(4-Chloro-2-fluorophenyl)piperazin-1-yl]aniline; 4-(4-Chloro-2-fluorophenyl)-1-(2-aminophenyl)piperazine; 2-(4-(4-Chloro-2-fluorophenyl)piperazin-1-yl)benzenamine; CAS 2006277-40-1; 4-Chloro-2-fluoro-1-[4-(2-aminophenyl)-1-piperazinyl]benzene
EINECS	Contact for details

Quality Control

Our production of 2-[4-(4-Chloro-2-Fluorophenyl)-1-Piperazinyl]Aniline adheres to stringent internal quality standards, ensuring batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by modern analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening sealed containers. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.