Description

3,5-Bis(Trifluoromethyl)Phenyl Diphenylphosphine Oxide is a high-value, specialty organophosphorus compound featuring a highly electron-deficient aryl backbone. This structure makes it a critical ligand and intermediate in advanced catalytic processes and materials science. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty polymer industries for constructing complex molecules and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key building block or ligand precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated motifs.
• Catalysis & Ligand Chemistry: Used as a precursor to generate Buchwald-type phosphine ligands for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, amination).
• Agrochemical Synthesis: Employed in the development of advanced, fluorinated pesticides and herbicides, where the trifluoromethyl groups enhance biological activity and stability.
• Materials Science: Acts as a monomer or additive in the creation of specialty polymers, flame retardants, and electronic materials.
• Organic Light-Emitting Diodes (OLEDs): Investigated as an electron-transport material or host material in emissive layers due to its electronic properties.
• Academic & Industrial Research: A valuable reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenyl Diphenylphosphine Oxide
CAS No.	299176-62-8
Molecular Formula	C21H13F6OP
Molecular Weight	426.29 g/mol
Synonyms	[3,5-Bis(trifluoromethyl)phenyl]diphenylphosphine oxide; Diphenyl[3,5-bis(trifluoromethyl)phenyl]phosphine oxide; (3,5-Bis(trifluoromethyl)phenyl)(diphenyl)phosphine oxide; 3,5-Bis(trifluoromethyl)phenyl-diphenylphosphine oxide; P,P-Diphenyl-P-[3,5-bis(trifluoromethyl)phenyl]phosphine oxide
EINECS	Contact for details

Quality Control

Every batch of 3,5-Bis(Trifluoromethyl)Phenyl Diphenylphosphine Oxide is produced and analyzed under strict quality management protocols. We ensure high purity and consistency through advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.