Description

H2N-Peg6-Ch2Cootbu CAS NO 297162-50-6 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group and a tert-butyl ester-protected carboxylic acid. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the controlled linkage of molecules with precise spacing and solubility. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science for creating PEGylated therapeutics, diagnostic agents, and functionalized surfaces.

Application

• Bioconjugation Linker: Used to covalently attach peptides, proteins, or antibodies to other molecules, surfaces, or nanoparticles via its amine-reactive and carboxyl-reactive ends.
• PEGylation Reagent: Serves as a spacer arm to modify therapeutic proteins and peptides, enhancing their solubility, stability, and circulation half-life in vivo.
• ADC (Antibody-Drug Conjugate) Development: A key intermediate for constructing linkers that connect cytotoxic payloads to monoclonal antibodies in targeted cancer therapies.
• Surface Functionalization: Employed to modify materials and biosensor surfaces with amine-reactive groups for subsequent biomolecule immobilization.
• Cross-linking Agent: Facilitates the formation of hydrogels or polymer networks for drug delivery systems and tissue engineering scaffolds.
• Diagnostic Probe Synthesis: Used in the preparation of fluorescent or radioactive probes for imaging and diagnostic applications.

Basic Information

Item	Detail
Product Name	H2N-Peg6-Ch2Cootbu
CAS No.	297162-50-6
Molecular Formula	C25H51NO10
Molecular Weight	525.68 g/mol
Synonyms	6-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid tert-butyl ester; 1-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid tert-butyl ester; tert-Butyl 17-amino-4,7,10,13,16-pentaoxa-3-azaheptadecan-1-oate; Amine-PEG6-t-butyl ester; NH2-PEG6-COOtBu; Amino-PEG6-acid t-butyl ester; H2N-PEG6-CH2COOH-tBu; Amino-PEG6-C2-acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our H2N-Peg6-Ch2Cootbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research and GMP applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a desiccator to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.