Description

(R)-3-(Pyrrolidin-2-Yl)Pyridine Dihydrochloride is a high-purity chiral intermediate and building block of significant interest in advanced organic synthesis. Its value lies in its role as a key precursor for the development of novel pharmaceutical compounds, particularly those targeting neurological and psychiatric disorders. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel nicotinic acetylcholine receptor (nAChR) ligands and other central nervous system (CNS) active compounds.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the research and development of potential therapeutics for cognitive disorders and addiction.
• Asymmetric Synthesis: Utilized in stereoselective synthesis routes to create enantiomerically pure compounds for medicinal chemistry programs.
• Biochemical Research: Employed as a reference standard or probe in pharmacological studies targeting specific neurotransmitter systems.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.

Basic Information

Product Name	(R)-3-(Pyrrolidin-2-Yl)Pyridine Dihydrochloride
CAS No.	288247-82-5
Molecular Formula	C9H14N2·2HCl
Molecular Weight	231.14 g/mol
Synonyms	(R)-3-(2-Pyrrolidinyl)pyridine dihydrochloride; (R)-3-Pyrrolidin-2-yl-pyridine dihydrochloride; (R)-3-(Pyrrolidin-2-yl)pyridine hydrochloride (1:2); (R)-2-(3-Pyridyl)pyrrolidine dihydrochloride; (R)-Anabasine dihydrochloride; (R)-Neonicotine dihydrochloride; (2R)-3-(Pyrrolidin-2-yl)pyridine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-(Pyrrolidin-2-Yl)Pyridine Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality system is designed to support customer requirements for pre-clinical and clinical-stage material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.