Description

3-Ethynyl-3-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, multifunctional piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both a reactive ethynyl group and a protected carboxylic acid, makes it indispensable for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential kinase inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for targeted therapies.
• Agrochemical Synthesis: Used in the creation of advanced, high-efficacy crop protection agents with specific modes of action.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics & Bioactive Molecules: Incorporated into the backbone of peptide analogs and other bioactive compounds to modulate their properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways due to its alkyne "click chemistry" handle.
• Material Science Research: Acts as a monomer or cross-linker in the development of specialized polymers with tailored functionalities.

Basic Information

Product Name	3-Ethynyl-3-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	287192-85-2
Molecular Formula	C12H19NO3
Molecular Weight	225.28 g/mol
Synonyms	1-Boc-3-ethynyl-3-hydroxypiperidine; tert-Butyl 3-ethynyl-3-hydroxypiperidine-1-carboxylate; 3-Ethynyl-3-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 3-Hydroxy-3-ethynylpiperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-ethynyl-3-hydroxypiperidine; N-Boc-3-ethynyl-3-hydroxypiperidine; 3-Ethynyl-3-hydroxy-N-Boc-piperidine
EINECS	Contact for details

Quality Control

Our production of 3-Ethynyl-3-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH guidelines, and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.