Description

(2S)-1-Boc-β-Oxo-2-Piperidinepropanoic Acid Ethyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic utility. This compound is valued for its role in constructing complex molecular architectures, particularly in the synthesis of bioactive molecules and active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for process development and scale-up.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those containing piperidine or proline-like motifs.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and constrained peptides for medicinal chemistry applications.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in stereoselective organic synthesis, leveraging its Boc-protected amine and ester functionalities.
• API Development: Employed in the research and development stages for creating novel Active Pharmaceutical Ingredients (APIs) targeting neurological and metabolic disorders.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes for studying biological mechanisms and enzyme inhibition.
• Agrochemical Synthesis: Can be utilized as an intermediate in the production of certain chiral agrochemicals.

Basic Information

Product Name	(2S)-1-Boc-β-Oxo-2-Piperidinepropanoic Acid Ethyl Ester
CAS No.	287107-84-0
Molecular Formula	C15H25NO5
Molecular Weight	299.36 g/mol
Synonyms	Ethyl (2S)-1-[(tert-Butoxy)carbonyl]-3-oxo-2-piperidinepropanoate; (2S)-1-(tert-Butoxycarbonyl)-3-oxo-2-piperidinepropanoic Acid Ethyl Ester; 1-Boc-3-oxo-L-homopipecolic Acid Ethyl Ester; (S)-1-Boc-3-oxo-2-piperidinepropanoic Acid Ethyl Ester; Ethyl 1-Boc-3-oxo-L-homopipecolate; (S)-Ethyl 1-Boc-3-oxo-2-piperidinepropanoate; L-Homopipecolic acid, 1-N-Boc-3-oxo-, ethyl ester; 287107-84-0
EINECS	Contact for details

Quality Control

Our (2S)-1-Boc-β-Oxo-2-Piperidinepropanoic Acid Ethyl Ester is manufactured under controlled conditions to ensure high chemical and chiral purity, meeting the stringent requirements of advanced synthetic applications. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and optical rotation measurement, to verify identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with internal quality standards for research and cGMP-guided production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.