Description

1-Methanesulfonyl-Piperidine-4-Carboxylic Acid is a high-purity, functionalized piperidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of new active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce sulfonyl and carboxylic acid functionalities into target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its piperidine core for bioactivity.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating molecular probes to study enzyme function and protein-protein interactions.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: A starting material for custom synthesis projects requiring a specific, functionalized heterocycle for downstream transformations.

Basic Information

Product Name	1-Methanesulfonyl-Piperidine-4-Carboxylic Acid
CAS No.	280772-00-1
Molecular Formula	C8H15NO4S
Molecular Weight	221.27 g/mol
Synonyms	4-Piperidinecarboxylic acid, 1-(methylsulfonyl)-; 1-(Methylsulfonyl)piperidine-4-carboxylic acid; 1-Methanesulfonylpiperidine-4-carboxylic acid; Piperidine-4-carboxylic acid, 1-methanesulfonyl-; NSC 405124; 1-Mesyl-piperidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Methanesulfonyl-Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high standards, including cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.