Description

(R)-n-1-Boc-4-Cbz-2-Piperazinecarboxylic Acid Methyl Ester is a high-purity, chiral piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for the development of novel pharmaceutical candidates, particularly in the creation of complex molecules with specific stereochemical requirements. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals where precise chirality control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Peptidomimetic Synthesis: Used to incorporate constrained, non-natural amino acid motifs into peptide backbones to enhance stability and bioavailability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric hydrogenation and other catalytic processes.
• API Development: Employed in the multi-step synthesis of complex, stereochemically defined Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Research: Utilized as a probe or building block in the study of biological pathways and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital component for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	(R)-n-1-Boc-4-Cbz-2-Piperazinecarboxylic Acid Methyl Ester
CAS No.	278790-00-4
Molecular Formula	C19H26N2O6
Molecular Weight	378.42 g/mol
Synonyms	(R)-1-Boc-4-Cbz-2-Piperazinecarboxylic Acid Methyl Ester; Methyl (R)-1-(tert-butoxycarbonyl)-4-(benzyloxycarbonyl)piperazine-2-carboxylate; (R)-1-N-Boc-4-N-Cbz-piperazine-2-carboxylic Acid Methyl Ester; (R)-Methyl 1-Boc-4-Cbz-piperazine-2-carboxylate; (R)-1-tert-Butyl 4-benzyl 2-methyl piperazine-1,2,4-tricarboxylate; (2R)-1-[(2-Methyl-2-propanyl)oxycarbonyl]-4-[(phenylmethoxy)carbonyl]-2-piperazinecarboxylic Acid Methyl Ester; Boc-Cbz-(R)-piperazine-2-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (R)-n-1-Boc-4-Cbz-2-Piperazinecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.