Description

(R)-2-(1H-Imidazol-1-Ylmethyl)-Morpholine 3Hcl CAS NO 278789-00-7 is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its specific stereochemistry and functional groups, which are critical for synthesizing active pharmaceutical ingredients (APIs) with targeted biological activity. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex molecules with high enantiomeric purity in medicinal chemistry.
• Ligand and Catalyst Development: Used in the design and synthesis of chiral ligands and organocatalysts for stereoselective transformations.
• Biochemical Research: Employed as a reference standard or probe in biochemical assays and pharmacological studies to investigate receptor interactions.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals and advanced materials requiring specific morpholine and imidazole motifs.

Basic Information

Product Name	(R)-2-(1H-Imidazol-1-Ylmethyl)-Morpholine 3Hcl
CAS No.	278789-00-7
Molecular Formula	C8H15N3O • 3HCl
Molecular Weight	298.60 g/mol (Free base: 169.23 g/mol)
Synonyms	(R)-2-((1H-Imidazol-1-yl)methyl)morpholine trihydrochloride; (R)-1-(Morpholin-2-ylmethyl)-1H-imidazole trihydrochloride; (R)-2-(Imidazol-1-ylmethyl)morpholine hydrochloride (3:1); UNII-7J3K4S4A2P; (2R)-2-(1H-Imidazol-1-ylmethyl)-4-morpholinamine trihydrochloride; (R)-2-(Imidazol-1-ylmethyl)morpholine trihydrochloride; (R)-SKF-96365 trihydrochloride (related derivative)
EINECS	Contact for details

Quality Control

Our (R)-2-(1H-Imidazol-1-Ylmethyl)-Morpholine 3Hcl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0% (Anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.