Description

Piperazine, 2-(1H-Imidazol-1-Ylmethyl)-1-Methyl-, (2R)- (9Ci) is a high-purity, chiral piperazine derivative of significant interest in advanced pharmaceutical synthesis. This compound matters as a sophisticated building block, offering a unique molecular scaffold that combines piperazine and imidazole pharmacophores for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for creating targeted therapies in areas such as oncology, neurology, and anti-infectives. The product is supplied under stringent quality control to ensure batch-to-batch consistency for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and oncological targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies due to its imidazole and piperazine functional groups.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis or as chelating agents in metal-organic frameworks (MOFs).
• Bioconjugation Chemistry: Potential use in creating linkers for antibody-drug conjugates (ADCs) or other targeted drug delivery systems.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes to study biological pathways and enzyme functions.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial manufacturing of advanced pharmaceutical intermediates.

Basic Information

Product Name	Piperazine, 2-(1H-Imidazol-1-Ylmethyl)-1-Methyl-, (2R)- (9Ci)
CAS No.	278788-69-5
Molecular Formula	C9H16N4
Molecular Weight	180.25 g/mol
Synonyms	(2R)-2-[(1H-Imidazol-1-yl)methyl]-1-methylpiperazine; 1-Methyl-2-((1H-imidazol-1-yl)methyl)-(R)-piperazine; (R)-1-Methyl-2-(imidazol-1-ylmethyl)piperazine; UNII-9J8K3A8U4Q; 9J8K3A8U4Q; (R)-N-Methyl-2-(imidazol-1-ylmethyl)piperazine; 2-[(Imidazol-1-yl)methyl]-1-methyl-(2R)-piperazine
EINECS	Contact for details

Quality Control

Our Piperazine, 2-(1H-Imidazol-1-Ylmethyl)-1-Methyl-, (2R)- (9Ci) is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical research. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We can support development with analytical method development and validation data. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.