Description

(R)-1-Boc-3-(Hydroxymethyl)Piperazine is a high-purity chiral piperazine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the simultaneous protection of the piperazine nitrogen and the presence of a hydroxymethyl handle, enabling precise and sequential functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• API Development: Used in constructing the core piperazine scaffolds found in numerous drug candidates targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Serves as a precursor for creating novel fungicides and herbicides with specific chiral activity.
• Ligand and Catalyst Preparation: The hydroxymethyl group allows for attachment to solid supports or metal centers, useful in asymmetric catalysis.
• Peptidomimetic Research: Employed in the design and synthesis of peptide analogs to improve metabolic stability and bioavailability.
• Custom Chemical Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	(R)-1-Boc-3-(Hydroxymethyl)Piperazine
CAS No.	278788-66-2
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine; (R)-3-(Hydroxymethyl)-1-Boc-piperazine; (R)-N-Boc-3-piperazinemethanol; (R)-1-Boc-3-piperazinemethanol; tert-Butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate; (R)-1-Boc-3-hydroxymethylpiperazine; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]piperazine-3-methanol; (R)-1-N-Boc-3-(hydroxymethyl)piperazine
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-3-(Hydroxymethyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.