Description

(R)-4-Boc-Piperazine-3-Carboxylic Acid is a high-purity, enantiomerically pure building block of significant importance in modern synthetic organic and medicinal chemistry. Its core value lies in providing a chiral, protected piperazine scaffold, which is a privileged structure for designing and synthesizing novel bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries, particularly for the development of new active pharmaceutical ingredients (APIs), drug candidates, and complex chemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Peptidomimetic Chemistry: Used to incorporate constrained, chiral piperazine motifs into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Research: Employed in the synthesis of labeled compounds, molecular probes, and tool compounds for studying biological pathways and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	(R)-4-Boc-Piperazine-3-Carboxylic Acid
CAS No.	278788-60-6
Molecular Formula	C10H18N2O4
Molecular Weight	230.26 g/mol
Synonyms	(R)-1-Boc-3-Carboxypiperazine; (R)-1-(tert-Butoxycarbonyl)piperazine-3-carboxylic Acid; (3R)-1-[(2-Methyl-2-propanyl)oxycarbonyl]-3-piperazinecarboxylic Acid; (R)-4-(tert-Butoxycarbonyl)piperazine-3-carboxylic Acid; (R)-N-Boc-3-piperazinecarboxylic Acid; (R)-1-N-Boc-piperazine-3-carboxylic Acid; (R)-Boc-Pip(3)-OH; (R)-Boc-3-Cpa-OH
EINECS	Contact for details

Quality Control

Our (R)-4-Boc-Piperazine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for advanced pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.