Description

(R)-4-(Benzyloxycarbonyl)Piperazine-2-Carboxylic Acid is a high-purity, chiral piperazine derivative that serves as a critical building block in modern organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, essential for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring precise chiral control.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Peptidomimetics Research: Used to introduce constrained piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for metal-catalyzed transformations and organocatalysts.
• Chemical Biology Probes: Utilized to create tagged or modified chemical probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A fundamental component for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates for client projects.

Basic Information

Product Name	(R)-4-(Benzyloxycarbonyl)Piperazine-2-Carboxylic Acid
CAS No.	276695-09-1
Molecular Formula	C13H16N2O4
Molecular Weight	264.28 g/mol
Synonyms	(R)-1-CBZ-Piperazine-2-carboxylic acid; (R)-4-(Benzyloxycarbonyl)-2-piperazinecarboxylic acid; (R)-1-N-CBZ-Piperazine-2-carboxylic Acid; (R)-N-Carbobenzyloxy-piperazine-2-carboxylic acid; (R)-Piperazine-2-carboxylic acid, 4-(benzyloxycarbonyl)-; (2R)-4-[(Benzyloxy)carbonyl]piperazine-2-carboxylic acid; (R)-1-Benzyloxycarbonylpiperazine-2-carboxylic acid; (R)-N-Cbz-Piperazine-2-Carboxylic Acid
EINECS	Contact for details

Quality Control

Our (R)-4-(Benzyloxycarbonyl)Piperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.