Description

(4-Piperazin-1-Yl-Phenyl)-Carbamic Acid tert-Butyl Ester Dihydrochloride is a high-purity chemical intermediate of significant importance in modern pharmaceutical research and development. Its core value lies in its role as a key building block for synthesizing complex molecules, particularly those targeting central nervous system and oncological pathways. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality intermediates for drug discovery and scale-up activities.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Process Chemistry & Scale-Up: Serves as a key starting material or intermediate in the development of robust, scalable synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Bioconjugation & Probe Development: The piperazine and protected amine functionalities make it suitable for creating chemical probes and bioconjugates for biological studies.

Basic Information

Product Name	(4-Piperazin-1-Yl-Phenyl)-Carbamic Acid tert-Butyl Ester Dihydrochloride
CAS No.	273727-52-9
Molecular Formula	C15H24N3O2 · 2HCl
Molecular Weight	367.30 g/mol (as dihydrochloride salt)
Synonyms	tert-Butyl (4-(piperazin-1-yl)phenyl)carbamate dihydrochloride; 1-Boc-4-(4-Aminophenyl)piperazine Dihydrochloride; N-Boc-4-(4-Aminophenyl)piperazine 2HCl; 4-(4-((tert-Butoxycarbonyl)amino)phenyl)piperazine Dihydrochloride; 4-(Piperazin-1-yl)aniline, N-Boc-protected, dihydrochloride; BOC-Piperazine-Phenylamine Dihydrochloride; CAS 273727-52-9
EINECS	Contact for details

Quality Control

Our (4-Piperazin-1-Yl-Phenyl)-Carbamic Acid tert-Butyl Ester Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.