Description

1-(4-(Trifluoromethoxy)Phenyl) Piperazin-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is essential for R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting neurological receptors.
• Research & Development: Used in academic and industrial R&D for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Process Chemistry: Serves as a standardized building block for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API manufacturing.
• Chemical Biology: Employed as a tool compound in biochemical assays and pharmacological studies to investigate specific biological pathways.

Basic Information

Product Name	1-(4-(Trifluoromethoxy)Phenyl) Piperazin-2-One Hydrochloride
CAS No.	267659-71-2
Molecular Formula	C11H12F3N2O2 • HCl
Molecular Weight	312.69 g/mol
Synonyms	1-[4-(Trifluoromethoxy)phenyl]-2-piperazinone hydrochloride; 1-(4-Trifluoromethoxyphenyl)piperazin-2-one HCl; 2-Piperazinone, 1-[4-(trifluoromethoxy)phenyl]-, hydrochloride; 4-(Trifluoromethoxy)phenylpiperazin-2-one hydrochloride; TFMPPZ HCl (abbrev.); 267659-71-2 (CAS); 1-(4-(Trifluoromethoxy)phenyl)piperazin-2-one monohydrochloride
EINECS	Contact for details

Quality Control

Our 1-(4-(Trifluoromethoxy)Phenyl) Piperazin-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.