Description

6-(tert-Butoxycarbonyl)-5,6,7,8-Tetrahydropyrido[3,4-B]Pyrazine-7-Carboxylic Acid CAS NO 264623-57-6 is a high-purity, protected heterocyclic carboxylic acid building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of complex pharmaceutical molecules, particularly in medicinal chemistry and drug discovery pipelines. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Medicinal Chemistry Research: Used in the design and construction of novel heterocyclic scaffolds for structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetic Synthesis: Serves as a constrained, bicyclic amino acid analog for creating peptide-like molecules with enhanced metabolic stability and bioavailability.
• Process Chemistry Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) from laboratory to pilot plant and commercial production.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds and molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services.

Basic Information

Product Name	6-(tert-Butoxycarbonyl)-5,6,7,8-Tetrahydropyrido[3,4-B]Pyrazine-7-Carboxylic Acid
CAS No.	264623-57-6
Molecular Formula	C₁₃H₁₇N₃O₄
Molecular Weight	279.29 g/mol
Synonyms	7-Carboxy-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-6-carboxylic acid tert-butyl ester; Boc-Pyrido[3,4-b]pyrazine-7-carboxylic acid; 6-Boc-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-7-carboxylic acid; tert-Butyl 7-carboxy-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-6-carboxylate; 264623-57-6; (6-tert-Butoxycarbonyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-7-yl)carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 6-(tert-Butoxycarbonyl)-5,6,7,8-Tetrahydropyrido[3,4-B]Pyrazine-7-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure the material meets the exacting standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Handle and store in accordance with good laboratory and chemical hygiene practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.