Description

3-Methyl-5-(Trifluoromethyl)Benzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the trifluoromethyl group, which imparts unique electronic and lipophilic properties to target molecules, enhancing their metabolic stability and bioavailability. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct complex active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl pharmacophore for enhanced drug-like properties.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the CF3 group improves compound penetration and environmental stability.
• Liquid Crystal & OLED Materials: Used in the production of advanced electronic materials and functional dyes due to its aromatic core and fluorine content.
• Polymer Chemistry: Monomer or modifying agent for specialty polymers, including high-performance resins and coatings with specific chemical resistance.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed reactions like Suzuki-Miyaura couplings for biaryl synthesis.
• Peptide & Protein Research: Acylation reagent for modifying amino acids or introducing fluorinated aromatic groups into biomolecules.

Basic Information

Product Name	3-Methyl-5-(Trifluoromethyl)Benzoyl Chloride
CAS No.	261952-09-4
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	3-Methyl-5-(trifluoromethyl)benzoyl chloride; 3-Methyl-alpha,alpha,α-trifluoro-m-toluoyl chloride; 5-(Trifluoromethyl)-3-methylbenzoyl chloride; m-Toluoyl chloride, 3-methyl-5-(trifluoromethyl)-; 3-Methyl-5-trifluoromethylbenzoyl chloride; Benzoyl chloride, 3-methyl-5-(trifluoromethyl)-; 261952-09-4
EINECS	Contact for details

Quality Control

Our 3-Methyl-5-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent high purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.