Description

1-Chloroacetyl-4-(3-Chloro-5-(Trifluoromethyl)Pyrid-2-Yl)Piperazine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is engineered to serve as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique piperazine and pyridine core enables precise molecular modifications. It is primarily sought by research and development teams, as well as process chemists, in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Active Ingredient Development: Used in creating advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethylpyridine moiety for enhanced efficacy and environmental profile.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening and lead optimization.
• Custom Synthesis & Contract Manufacturing: Serves as a specialized starting material for custom synthesis projects and scale-up production under cGMP conditions.
• Ligand & Catalyst Development: The piperazine nitrogen atoms can be utilized to develop novel ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Chloroacetyl-4-(3-Chloro-5-(Trifluoromethyl)Pyrid-2-Yl)Piperazine
CAS No.	260553-15-9
Molecular Formula	C12H10Cl2F3N3O
Molecular Weight	328.13 g/mol
Synonyms	1-Chloroacetyl-4-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]piperazine; 2-[4-(Chloroacetyl)piperazin-1-yl]-3-chloro-5-(trifluoromethyl)pyridine; 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(chloroacetyl)piperazine; N-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-(chloroacetyl)piperazine; 260553-15-9; CAS-260553-15-9
EINECS	Contact for details

Quality Control

Our 1-Chloroacetyl-4-(3-Chloro-5-(Trifluoromethyl)Pyrid-2-Yl)Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for pharmaceutical applications upon request, ensuring traceability and regulatory compliance for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen for long-term storage to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.