Description

4-(4-Bromo-Benzenesulfonyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a brominated benzenesulfonyl group and a Boc-protected piperazine ring. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with targeted biological activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel drug candidates, particularly in areas requiring sulfonamide-based pharmacophores.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, especially those containing sulfonamide functional groups.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic agents.
• Protease Inhibitor Synthesis: Employed in the construction of potential protease inhibitors, leveraging the sulfonyl-piperazine motif.
• Kinase Inhibitor Development: Serves as a precursor in the creation of small molecule kinase inhibitors for oncology and other disease areas.
• Chemical Biology Probes: Utilized to create specialized molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	4-(4-Bromo-Benzenesulfonyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	259808-63-4
Molecular Formula	C15H21BrN2O4S
Molecular Weight	405.31 g/mol
Synonyms	1-Boc-4-(4-bromophenylsulfonyl)piperazine; tert-Butyl 4-[(4-bromophenyl)sulfonyl]piperazine-1-carboxylate; 4-(4-Bromophenylsulfonyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(4-bromobenzenesulfonyl)piperazine; N-Boc-4-(4-bromobenzenesulfonyl)piperazine; Piperazine, 1-[(1,1-dimethylethoxy)carbonyl]-4-[(4-bromophenyl)sulfonyl]-; Boc-Piperazine-4-(4-Br-Ph-Sulfonyl)
EINECS	Contact for details

Quality Control

Our 4-(4-Bromo-Benzenesulfonyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from HPLC, NMR, and MS. Our quality commitment supports its use in critical research and development applications, with specifications tailored to meet both standard and custom project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.