Description

(3R,4R)-4-(4-(Benzyloxy)Phenyl)-1-((R)-1-Phenylethyl)Piperidin-3-Ol Hydrochloride is a high-purity chiral piperidine derivative, primarily utilized as a critical pharmaceutical intermediate. Its precise stereochemistry makes it a valuable building block for the synthesis of complex active pharmaceutical ingredients (APIs) targeting the central nervous system. This compound is essential for research and development laboratories and production facilities in the global pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development and manufacturing of novel therapeutic agents, particularly in neurology and psychiatry.
• Chemical Synthesis: Used in asymmetric synthesis and medicinal chemistry research to create libraries of compounds for biological screening.
• API Development: Serves as a precursor in the multi-step synthesis of potential drug candidates undergoing preclinical and clinical evaluation.
• Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(3R,4R)-4-(4-(Benzyloxy)Phenyl)-1-((R)-1-Phenylethyl)Piperidin-3-Ol Hydrochloride
CAS No.	257938-65-1
Molecular Formula	C26H29NO2·HCl
Molecular Weight	423.98 g/mol
Synonyms	(3R,4R)-4-(4-Benzyloxyphenyl)-1-[(1R)-1-phenylethyl]piperidin-3-ol hydrochloride; (3R,4R)-4-(4-(Benzyloxy)phenyl)-1-((R)-1-phenylethyl)piperidin-3-ol HCl; 1-(1-Phenylethyl)-4-(4-benzyloxyphenyl)-3-piperidinol hydrochloride (stereoisomer); UNII-9F6L5UJ3V7; 9F6L5UJ3V7; (3R,4R)-rel-4-[4-(Phenylmethoxy)phenyl]-1-[(1R)-1-phenylethyl]-3-piperidinol hydrochloride
EINECS	Contact for details

Quality Control

Our (3R,4R)-4-(4-(Benzyloxy)Phenyl)-1-((R)-1-Phenylethyl)Piperidin-3-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.