Description

Piperazine, 1-(Ethylsulfonyl)-4-[4-(Trifluoromethyl)-2-Pyridinyl]- is a high-value, heterocyclic organic compound featuring a piperazine core substituted with an ethylsulfonyl group and a trifluoromethylpyridinyl moiety. This specific molecular architecture makes it a critical advanced pharmaceutical intermediate (API) for the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical R&D and manufacturing sectors focused on developing novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Kinase Inhibitor Precursor: The trifluoromethylpyridine and sulfonyl piperazine motifs are common in the structure of protein kinase inhibitors, making this compound valuable for cancer research and drug discovery programs.
• Agrochemical Research: Used in the development of advanced fungicides and herbicides, leveraging its heterocyclic structure for biological activity.
• Material Science: Potential application as a monomer or functional additive in the synthesis of specialty polymers with unique electronic or surface properties.
• Chemical Synthesis: Employed in organic chemistry research as a versatile scaffold for constructing complex molecules for various screening libraries.

Basic Information

Product Name	Piperazine, 1-(Ethylsulfonyl)-4-[4-(Trifluoromethyl)-2-Pyridinyl]-
CAS No.	257862-73-0
Molecular Formula	C13H16F3N3O2S
Molecular Weight	335.35 g/mol
Synonyms	1-(Ethylsulfonyl)-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine; 4-[4-(Trifluoromethyl)-2-pyridinyl]-1-(ethylsulfonyl)piperazine; 2-[4-(Ethylsulfonyl)piperazin-1-yl]-4-(trifluoromethyl)pyridine; N-Ethylsulfonyl-4-(4-trifluoromethyl-2-pyridinyl)piperazine; 1-Ethanesulfonyl-4-(4-trifluoromethyl-pyridin-2-yl)-piperazine
EINECS	Contact for details

Quality Control

Our Piperazine, 1-(Ethylsulfonyl)-4-[4-(Trifluoromethyl)-2-Pyridinyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing assay, impurity profiles, and residual solvents. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.