Description

Piperazine, 1-[(4-Methyl-1,2,3-thiadiazol-5-yl)carbonyl]-4-[4-(trifluoromethyl)-2-pyridinyl]- is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, especially within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, leveraging its piperazine and trifluoromethylpyridine motifs.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Integral to the research and process development of new Active Pharmaceutical Ingredients, particularly for central nervous system (CNS) or anti-infective targets.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules for clinical trials.
• Agrochemical Research: Potential application as an intermediate in the development of novel agrochemicals due to its heterocyclic structure.

Basic Information

Product Name	Piperazine, 1-[(4-Methyl-1,2,3-thiadiazol-5-yl)carbonyl]-4-[4-(trifluoromethyl)-2-pyridinyl]-
CAS No.	257862-68-3
Molecular Formula	C14H12F3N5OS
Molecular Weight	355.34 g/mol
Synonyms	1-[(4-Methyl-1,2,3-thiadiazol-5-yl)carbonyl]-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine; 4-[4-(Trifluoromethyl)pyridin-2-yl]-1-[(4-methyl-1,2,3-thiadiazol-5-yl)carbonyl]piperazine; 1-(4-Methyl-1,2,3-thiadiazole-5-carbonyl)-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine; Piperazine derivative (CAS 257862-68-3); Advanced Pharmaceutical Intermediate 257862-68-3
EINECS	Contact for details

Quality Control

Our Piperazine, 1-[(4-Methyl-1,2,3-thiadiazol-5-yl)carbonyl]-4-[4-(trifluoromethyl)-2-pyridinyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.