Description

4-(4-[(R)-2-(2,4-Dichloro-Phenyl)-2-Imidazol-1-Ylmethyl-[1,3]Dioxolan-4-Ylmethoxy]-Phenyl)-Piperazine-1-Carboxylic Acid Methyl Ester is a sophisticated chiral intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the development of novel therapeutic agents, particularly those targeting fungal infections. Pharmaceutical R&D teams and fine chemical manufacturers need this high-purity intermediate to ensure the efficacy and consistency of their final active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary use as a critical chiral synthon in the synthesis of next-generation antifungal APIs.
• Biochemical Research: Serves as a reference standard and a tool compound in pharmacological studies targeting specific enzymatic pathways.
• Process Chemistry Development: Used in route scouting and optimization for scalable manufacturing of complex drug molecules.
• Contract Manufacturing (CMO): Supplied to custom synthesis organizations for the production of clinical trial materials and commercial drug substances.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and novel compound library generation.

Basic Information

Item	Details
Product Name	4-(4-[(R)-2-(2,4-Dichloro-Phenyl)-2-Imidazol-1-Ylmethyl-[1,3]Dioxolan-4-Ylmethoxy]-Phenyl)-Piperazine-1-Carboxylic Acid Methyl Ester
CAS No.	256417-54-6
Molecular Formula	C26H28Cl2N4O5
Molecular Weight	547.43 g/mol
Synonyms	(R)-4-(4-(2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine-1-carboxylate; Methyl (R)-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine-1-carboxylate; 256417-54-6; UNII-9VXA7S1B6P; SCHEMBL218064; AGR-2257; CHEMBL3185262; (R)-Enantiomer of Posaconazole Intermediate
EINECS	Contact for details

Quality Control

Our 4-(4-[(R)-2-(2,4-Dichloro-Phenyl)-2-Imidazol-1-Ylmethyl-[1,3]Dioxolan-4-Ylmethoxy]-Phenyl)-Piperazine-1-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity, to meet the exacting standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R)-enantiomer
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.