Description

2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Pyrimidine-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a piperazine-pyrimidine core protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers focused on developing therapeutics in areas such as oncology and central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable carboxylic acid and protected amine functionalities.
• API Development: Serves as a crucial precursor in the development and scale-up of new active pharmaceutical ingredients (APIs).
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of specialized compounds for client R&D projects.
• Bioconjugation & Probe Development: The carboxylic acid group allows for coupling to other molecules, useful in creating biochemical probes or antibody-drug conjugates (ADCs).

Basic Information

Product Name	2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Pyrimidine-5-Carboxylic Acid
CAS No.	253315-11-6
Molecular Formula	C14H20N4O4
Molecular Weight	308.34 g/mol
Synonyms	2-[4-[(2-Methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]pyrimidine-5-carboxylic acid; 2-(4-Boc-piperazin-1-yl)pyrimidine-5-carboxylic acid; 1-Boc-4-(5-carboxypyrimidin-2-yl)piperazine; tert-Butyl 4-(5-carboxypyrimidin-2-yl)piperazine-1-carboxylate; 2-(1-Boc-4-piperazinyl)-5-pyrimidinecarboxylic acid; Boc-Pip-Pym-COOH; CAS 253315-11-6
EINECS	Contact for details

Quality Control

Our 2-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Pyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.