Description

Ertiprotafib CAS NO 251303-04-5 is a potent and selective small molecule inhibitor of protein tyrosine phosphatase 1B (PTP1B). This compound is a critical research tool for investigating insulin and leptin signaling pathways, offering significant value in metabolic disease research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for diabetes and obesity.

Application

• Biochemical Research: A key tool compound for studying the role of PTP1B in cellular signaling cascades related to insulin and leptin resistance.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in preclinical studies for metabolic disorders, including type 2 diabetes and obesity.
• Target Validation: Used in vitro and in vivo to validate PTP1B as a therapeutic target for metabolic and potentially oncological applications.
• Academic Research: Employed in university and institutional labs to explore the fundamental mechanisms of tyrosine phosphatase biology and signal transduction.
• High-Throughput Screening (HTS): Acts as a control or reference inhibitor in assay development and screening campaigns targeting phosphatase activity.

Basic Information

Product Name	Ertiprotafib
CAS No.	251303-04-5
Molecular Formula	C23H20N2O5S
Molecular Weight	436.48 g/mol
Synonyms	PTP1B Inhibitor; 2-Methoxy-5-[[(4-phenylbutoxy)carbonyl]amino]-N-(2-pyridinylmethyl)benzenesulfonamide; 2-Methoxy-5-({[4-(phenyl)butoxy]carbonyl}amino)-N-(pyridin-2-ylmethyl)benzenesulfonamide; PTP-1B Inhibitor; ABT-963; Benzenesulfonamide, 2-methoxy-5-[[[4-(phenyl)butoxy]carbonyl]amino]-N-2-pyridinylmethyl-
EINECS	Contact for details

Quality Control

Our Ertiprotafib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.