Description

tert-Butyl 4-tosylpiperazine-1-carboxylate is a high-purity, protected piperazine derivative serving as a critical building block in modern organic synthesis. This compound is essential for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and process development. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of new drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis: Serves as a starting material for the contract manufacturing of specialized fine chemicals and advanced intermediates.
• Chemical Biology: Useful in the synthesis of molecular probes and tool compounds for biological target identification and validation.

Basic Information

Product Name	tert-Butyl 4-Tosylpiperazine-1-Carboxylate
CAS No.	250331-04-5
Molecular Formula	C16H24N2O4S
Molecular Weight	340.44 g/mol
Synonyms	1-Boc-4-(4-methylphenylsulfonyl)piperazine; tert-Butyl 4-(4-methylphenylsulfonyl)-1-piperazinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(p-tolylsulfonyl)piperazine; 4-(p-Toluenesulfonyl)-1-piperazinecarboxylic acid tert-butyl ester; 1-Boc-4-tosylpiperazine; Boc-4-Tosylpiperazine; N-Boc-4-(p-toluenesulfonyl)piperazine; 4-Tosyl-1-piperazinecarboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-tosylpiperazine-1-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All material is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.