Description

7α,24(S)-Dihydroxycholesterol is a specific, high-purity oxysterol derivative of cholesterol, identified by CAS NO 245523-67-5. This compound serves as a critical biochemical standard and research tool for investigating cholesterol metabolism, lipid signaling pathways, and liver X receptor (LXR) activity. It is essential for researchers and developers in the pharmaceutical, biotechnology, and life science sectors who require precise reference materials for analytical method development, metabolic studies, and drug discovery programs.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in LC-MS, GC-MS, and HPLC analyses for the quantification of oxysterols in biological samples.
• Metabolic Pathway Studies: A key intermediate for studying the alternative (acidic) pathway of bile acid biosynthesis and other cholesterol catabolic processes.
• Cell Signaling & Receptor Research: Investigated as a potential endogenous ligand or modulator for nuclear receptors such as Liver X Receptors (LXRs), which regulate cholesterol homeostasis and inflammation.
• Pharmaceutical Development: Employed in screening assays and as a starting material for the synthesis of more complex molecules targeting metabolic diseases.
• Diagnostic Kit Manufacturing: Utilized in the calibration and validation of diagnostic assays measuring oxysterol levels for research into neurodegenerative and cardiovascular diseases.

Basic Information

Product Name	7α,24(S)-Dihydroxycholesterol
CAS No.	245523-67-5
Molecular Formula	C27H46O3
Molecular Weight	418.66 g/mol
Synonyms	(24S)-7α,24-Dihydroxycholesterol; 7α,24(S)-Dihydroxycholest-5-en-3β-ol; 5-Cholestene-3β,7α,24(S)-triol; 24(S)-Hydroxy-7α-hydroxycholesterol; 7α,24S-Dihydroxycholesterol; 7α,24-Dihydroxy-5-cholesten-3β-ol; 7α,24(S)-DHChol
EINECS	Contact for details

Quality Control

Our 7α,24(S)-Dihydroxycholesterol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to cGMP principles for research chemicals, and our quality system supports compliance with global regulatory standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in ethanol, DMSO; slightly soluble in chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.