Description

(S)-2-Amino-1-(4-Methyl-1-Piperazinyl)-1-Propanone 2Hcl is a high-purity chiral piperazine derivative supplied as a dihydrochloride salt. This compound is a critical advanced pharmaceutical intermediate, valued for its role in the synthesis of complex active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel therapeutic agents and high-value chemical products.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly in central nervous system (CNS) and other therapeutic areas.
• API Synthesis: Used in the research, development, and scale-up production of active pharmaceutical ingredients (APIs) requiring a specific (S)-configured amino ketone moiety.
• Chemical Research & Development: Serves as a versatile precursor in organic synthesis for creating novel chemical entities in academic and industrial R&D laboratories.
• Agrochemical Intermediates: Employed in the development of advanced, high-performance agrochemicals and plant protection agents.
• Catalyst & Ligand Preparation: Can be utilized for the synthesis of chiral catalysts and ligands used in asymmetric synthesis.

Basic Information

Product Name	(S)-2-Amino-1-(4-Methyl-1-Piperazinyl)-1-Propanone 2Hcl
CAS No.	245487-62-1
Molecular Formula	C8H18N3O • 2HCl
Molecular Weight	283.17 g/mol (Free base: 172.25 g/mol)
Synonyms	(S)-2-Amino-1-(4-methylpiperazin-1-yl)propan-1-one dihydrochloride; (S)-1-(4-Methylpiperazin-1-yl)-2-aminopropan-1-one dihydrochloride; (S)-2-Amino-1-(4-methyl-1-piperazinyl)-1-propanone dihydrochloride; (S)-Ketamine Intermediate; (S)-NK1; AR-R 15896AR dihydrochloride; (S)-2-Amino-1-piperazinopropanone 2HCl
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-1-(4-Methyl-1-Piperazinyl)-1-Propanone 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, chiral purity analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.