Description

2,2,2-Trifluoro-1-(Piperazin-1-Yl)Ethanone Hydrochloride is a high-purity trifluoroacetyl piperazine derivative, a crucial building block in modern pharmaceutical synthesis. Its value lies in providing a reactive trifluoroacetyl group attached to a versatile piperazine scaffold, enabling the development of compounds with enhanced metabolic stability and bioavailability. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients, particularly in areas like central nervous system (CNS) agents and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in medicinal chemistry research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that require fluorine-containing motifs for improved efficacy.
• Chemical Biology & Proteomics: Serves as a reagent for modifying peptides and proteins, exploiting the reactivity of the trifluoroacetyl group.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials where fluorine incorporation is desired for specific properties like chemical resistance.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic and fluorine chemistry.

Basic Information

Product Name	2,2,2-Trifluoro-1-(Piperazin-1-Yl)Ethanone Hydrochloride
CAS No.	245487-45-0
Molecular Formula	C7H10F3N2O·HCl
Molecular Weight	232.62 g/mol (Free base: 196.16 g/mol)
Synonyms	1-(2,2,2-Trifluoroacetyl)piperazine hydrochloride; 2,2,2-Trifluoro-1-piperazin-1-ylethanone hydrochloride; N-(Trifluoroacetyl)piperazine hydrochloride; Piperazine, 1-(trifluoroacetyl)-, hydrochloride; Trifluoroacetylpiperazine HCl; TFA-Piperazine·HCl
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(Piperazin-1-Yl)Ethanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high standards, including cGMP-compliant production for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.