Description

Lidorestat CAS NO 245116-90-9 is a potent and selective inhibitor of the enzyme aldose reductase, a key target in the management of diabetic complications. This compound is of significant interest for its potential to prevent or delay the onset of diabetic neuropathy, retinopathy, and nephropathy by inhibiting the polyol pathway. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in metabolic disorder research and novel therapeutic development.

Application

• Pharmaceutical R&D: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of therapeutics for diabetic complications.
• Biochemical Research: Used as a selective tool compound in enzymatic assays and studies to investigate the polyol pathway's role in cellular metabolism and oxidative stress.
• Preclinical Studies: Employed in animal models of diabetes to evaluate the efficacy and pharmacokinetics of aldose reductase inhibition.
• Mechanism of Action Studies: Essential for structure-activity relationship (SAR) studies aimed at designing next-generation aldose reductase inhibitors with improved potency and selectivity.

Basic Information

Product Name	Lidorestat
CAS No.	245116-90-9
Molecular Formula	C15H12F3N3O3S
Molecular Weight	371.33 g/mol
Synonyms	Fidarestat; (2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide; SNK-860; AS-3201; Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2'-carboxamide, 6-fluoro-2,5-dioxo-, (4S,4'S)-; Aldose Reductase Inhibitor AS-3201; Lidorestatum
EINECS	Contact for details

Quality Control

Our Lidorestat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and MS. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.