Description

2-Bromo-5,6-Diphenylpyrazine is a high-purity brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its versatile reactivity, particularly in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it serves as a key precursor for active pharmaceutical ingredients (APIs), functional ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging its diphenylpyrazine core for bioactivity.
• Material Science & OLED Development: Serves as a precursor for electron-transport materials and host molecules in organic light-emitting diodes (OLEDs) due to its rigid, conjugated structure.
• Ligand Synthesis for Catalysis: Employed in the preparation of specialized nitrogen-containing ligands for transition metal catalysis.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis, including Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	2-Bromo-5,6-Diphenylpyrazine
CAS No.	243472-70-0
Molecular Formula	C16H11BrN2
Molecular Weight	311.18 g/mol
Synonyms	2-Bromo-5,6-diphenylpyrazine; 5,6-Diphenyl-2-bromopyrazine; 2-Bromodiphenylpyrazine; Pyrazine, 2-bromo-5,6-diphenyl-; 243472-70-0; 2-Br-5,6-DPP; 2-Bromo-5,6-diphenyl-1,4-diazine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5,6-Diphenylpyrazine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity, typically meeting standards of ≥98% (HPLC). Our quality assurance protocol includes identity confirmation (IR, NMR), purity assay (HPLC), and control of specified impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.