Description

2-Bromo-5-Phenylpyrazine is a versatile brominated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for coupling reactions and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its phenylpyrazine core.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Ligand Preparation: Utilized in the development of novel chelating ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research: A valuable reagent for academic and industrial R&D focused on heterocyclic chemistry and medicinal chemistry.

Basic Information

Product Name	2-Bromo-5-Phenylpyrazine
CAS No.	243472-69-7
Molecular Formula	C10H7BrN2
Molecular Weight	235.08 g/mol
Synonyms	5-Phenyl-2-bromopyrazine; 2-Bromo-5-phenylpyrazine; 2-Brom-5-phenylpyrazin (German); Pyrazine, 2-bromo-5-phenyl-; Bromo-5-phenylpyrazine; 243472-69-7; 2-Bromo-5-phenyl-pyrazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Phenylpyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.