Description

1-Boc-4-(Hydroxymethyl)-4-Methyl-Piperidine CAS NO 236406-21-6 is a high-purity, protected piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its dual functionality, offering both a reactive hydroxymethyl group and a Boc-protected amine, which provides orthogonal protection strategies. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of complex molecules, including active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, particularly those containing piperidine or piperazine scaffolds.
• Peptidomimetic Chemistry: Used to introduce constrained, functionalized heterocyclic units into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral auxiliaries, organocatalysts, and metal-complexing ligands in asymmetric synthesis.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that require functionalized nitrogen heterocycles.
• Material Science: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored properties.
• Chemical Biology Probes: Utilized to create tagged or labeled molecules for studying biological pathways and target engagement.

Basic Information

Product Name	1-Boc-4-(Hydroxymethyl)-4-Methyl-Piperidine
CAS No.	236406-21-6
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	4-(Hydroxymethyl)-4-methylpiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(hydroxymethyl)-4-methylpiperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(hydroxymethyl)-4-methylpiperidine; 4-Methyl-4-piperidinemethanol, 1-Boc protected; N-Boc-4-(hydroxymethyl)-4-methylpiperidine; Boc-4-(hydroxymethyl)-4-methylpiperidine; 1-Boc-4-methyl-4-piperidinemethanol
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(Hydroxymethyl)-4-Methyl-Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide full traceability and Certificates of Analysis (COA) for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.