Description

Benzyl 3-Oxo-4-(Prop-2-Ynyl)-Piperazine-1-Carboxylate is a high-purity synthetic intermediate featuring a piperazine core functionalized with a propargyl group and a benzyloxycarbonyl (Cbz) protecting group. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and complex heterocyclic molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing advanced molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile reactive sites.
• Peptidomimetic Synthesis: Serves as a constrained scaffold or a conformational constraint element in the design of peptide mimics.
• Chemical Biology Probes: The alkyne (prop-2-ynyl) moiety allows for bioorthogonal conjugation via click chemistry (e.g., CuAAC) for labeling and target identification studies.
• Agrochemical Development: Used as a precursor in the research and development of new crop protection agents and pesticides.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and the synthesis of novel chemical entities.

Basic Information

Product Name	Benzyl 3-Oxo-4-(Prop-2-Ynyl)-Piperazine-1-Carboxylate
CAS No.	234108-42-0
Molecular Formula	C15H16N2O3
Molecular Weight	272.30 g/mol
Synonyms	1-Carbobenzyloxy-3-oxo-4-propargylpiperazine; Benzyl 4-(2-Propynyl)-3-oxo-1-piperazinecarboxylate; 4-Propargyl-3-oxopiperazine-1-carboxylic acid benzyl ester; 1-N-Cbz-4-propargyl-3-oxopiperazine; 1-(Benzyloxycarbonyl)-4-(prop-2-yn-1-yl)piperazine-2-one; 234108-42-0; Cbz-4-Propargyl-3-oxopiperazine
EINECS	Contact for details

Quality Control

Our Benzyl 3-Oxo-4-(Prop-2-Ynyl)-Piperazine-1-Carboxylate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and development under cGMP-like controls where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.