Description

Ethyl 4-((3S,5R)-3,5-Dimethylpiperazin-1-yl)benzoate is a high-purity, chiral piperazine derivative serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and fine chemical industries seeking to develop novel drug candidates with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• API Development: Used in constructing the core pharmacophore of potential APIs that require the specific (3S,5R) stereochemistry of the dimethylpiperazine moiety.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize potency, selectivity, and metabolic profile of lead compounds.
• Process Chemistry & Scale-Up: Serves as a defined starting material for developing robust, scalable synthetic routes under current Good Manufacturing Practice (cGMP) standards.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in asymmetric catalytic reactions to introduce stereogenic centers.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in regulatory filings.

Basic Information

Product Name	Ethyl 4-((3S,5R)-3,5-Dimethylpiperazin-1-yl)benzoate
CAS No.	234082-05-4
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	Ethyl 4-[(3S,5R)-3,5-Dimethyl-1-piperazinyl]benzoate; Benzoic acid, 4-[(3S,5R)-3,5-dimethyl-1-piperazinyl]-, ethyl ester; (3S,5R)-1-(4-Ethoxycarbonylphenyl)-3,5-dimethylpiperazine; Ethyl p-((3S,5R)-3,5-dimethylpiperazino)benzoate; 234082-05-4; (S,R)-Ethyl 4-(3,5-dimethylpiperazin-1-yl)benzoate
EINECS	Contact for details

Quality Control

Our Ethyl 4-((3S,5R)-3,5-Dimethylpiperazin-1-yl)benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity, with specifications tailored to meet the stringent requirements of pharmaceutical R&D and production. Certificates of Analysis (COA) detailing results for assay, chiral purity, related substances, and residual solvents are provided with every shipment. We support development with research-grade to cGMP-compliant material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (for (3S,5R) isomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.