Description

Cyclobutanecarboxylic Acid, 3,3-Difluoro-1-Methyl- (9Ci) is a high-value, fluorinated cyclobutane derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a carboxylic acid group on a difluorinated cyclobutane ring, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorinated cyclobutane moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty materials designed for unique thermal, chemical, or surface properties.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme mechanisms and biological pathways due to the strategic placement of fluorine atoms.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3,3-Difluoro-1-Methyl- (9Ci)
CAS No.	227607-43-4
Molecular Formula	C6H8F2O2
Molecular Weight	150.12 g/mol
Synonyms	3,3-Difluoro-1-methylcyclobutanecarboxylic acid; 1-Methyl-3,3-difluorocyclobutanecarboxylic acid; 3,3-Difluoro-1-methyl-cyclobutanecarboxylic acid; 227607-43-4; Cyclobutanecarboxylic acid, 3,3-difluoro-1-methyl-; 3,3-Difluoromethylcyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of Cyclobutanecarboxylic Acid, 3,3-Difluoro-1-Methyl- (9Ci) is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the exacting standards required for research and scale-up activities. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and GC-MS is supplied with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.