Description

4-(4-Bromo-Benzenesulfonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its sulfonyl and piperidine functional groups. This compound is of critical importance for medicinal chemists in the research and development of novel active pharmaceutical ingredients (APIs), particularly in the areas of kinase inhibitors and central nervous system (CNS) therapeutics. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for constructing complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• Protease & Kinase Inhibitor Synthesis: Serves as a core scaffold for developing inhibitors due to its sulfonamide and piperidine motifs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development and quality control.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and chemical biology studies.

Basic Information

Product Name	4-(4-Bromo-Benzenesulfonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	226398-62-5
Molecular Formula	C16H22BrNO4S
Molecular Weight	404.32 g/mol
Synonyms	1-Boc-4-(4-Bromophenylsulfonyl)piperidine; tert-Butyl 4-[(4-bromophenyl)sulfonyl]piperidine-1-carboxylate; 4-(4-Bromobenzenesulfonyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(4-bromophenylsulfonyl)piperidine; N-Boc-4-(4-Bromobenzenesulfonyl)piperidine; 4-(p-Bromobenzenesulfonyl)-1-N-Boc-piperidine; 4-(4-Bromo-Benzenesulfonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our 4-(4-Bromo-Benzenesulfonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.