Description

1-tert-Butyl-4-Ethyl 4-(4-Fluorophenylthio)Piperidine-1,4-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine dicarboxylate core and fluorophenylthio substituent. This compound is critical for enabling the synthesis of complex active pharmaceutical ingredients (APIs) with enhanced biological activity and metabolic stability. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new therapeutic agents and crop protection solutions.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of novel small-molecule drugs, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research & Development: Used in the synthesis of advanced crop protection agents and pesticides, leveraging the fluorine moiety for improved efficacy.
• Chemical Biology & Proteomics: Employed as a specialized scaffold or linker in the design of chemical probes for target identification and validation studies.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality intermediate for optimizing synthetic routes and transitioning from laboratory to pilot and commercial-scale production.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental research in medicinal chemistry and organic synthesis methodologies.

Basic Information

Product Name	1-tert-Butyl-4-Ethyl 4-(4-Fluorophenylthio)Piperidine-1,4-Dicarboxylate
CAS No.	226396-62-9
Molecular Formula	C19H26FNO4S
Molecular Weight	383.48 g/mol
Synonyms	1-(tert-Butyl) 4-ethyl 4-[(4-fluorophenyl)sulfanyl]piperidine-1,4-dicarboxylate; 4-(4-Fluorophenylthio)piperidine-1,4-dicarboxylic acid 1-tert-butyl 4-ethyl ester; Ethyl 1-tert-butoxycarbonyl-4-(4-fluorophenylthio)-4-piperidinecarboxylate; 1-Boc-4-(4-fluorophenylthio)-4-(ethoxycarbonyl)piperidine; 4-(4-Fluorophenylthio)-1,4-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester; 1-N-Boc-4-(4-fluorophenylthio)-4-(ethoxycarbonyl)piperidine; 4-(p-Fluorophenylthio)piperidine-1,4-dicarboxylic acid tert-butyl ethyl diester
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butyl-4-Ethyl 4-(4-Fluorophenylthio)Piperidine-1,4-Dicarboxylate adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with the standards required for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.