Description

Cinacalcet CAS NO 226256-56-0 is a potent calcimimetic agent that acts as an allosteric modulator of the calcium-sensing receptor (CaSR). This compound is critical for the precise regulation of calcium homeostasis in therapeutic applications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in developing and producing treatments for secondary hyperparathyroidism and related mineral metabolism disorders.

Application

• Active Pharmaceutical Ingredient (API): Core component in the manufacture of calcimimetic medications for controlling parathyroid hormone (PTH) secretion.
• Treatment of Secondary Hyperparathyroidism (SHPT): Used in formulations for patients with chronic kidney disease (CKD) on dialysis.
• Research & Development: Serves as a key reference standard and investigational compound in endocrine and renal disease research.
• Pharmaceutical Intermediates: Utilized in the synthesis of more complex drug formulations and novel therapeutic agents targeting the CaSR.
• Clinical Trial Materials: Supplied as a high-purity compound for pre-clinical and clinical studies.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent versions of established calcimimetic therapies.

Basic Information

Product Name	Cinacalcet
CAS No.	226256-56-0
Molecular Formula	C22H22F3N
Molecular Weight	357.42 g/mol
Synonyms	N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; Cinacalcet Hydrochloride (salt form); AMG 073; Sensipar (brand name); Mimpara (brand name); (R)-N-[1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
EINECS	Contact for details

Quality Control

Our Cinacalcet is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure compliance with pharmaceutical-grade specifications, including identity, purity, and impurity profile verification. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results from HPLC, NMR, and other relevant pharmacopeial tests.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.