Description

(S)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester CAS NO 225517-81-7 is a high-purity chiral piperazine derivative, serving as a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with targeted biological activity. This intermediate is essential for research and development chemists in the pharmaceutical and biotechnology industries, particularly for creating novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and constrained peptides to improve metabolic stability and bioavailability.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis routes.
• API Development: Integral in the development and scale-up processes for new active pharmaceutical ingredients requiring a piperazine core.

Basic Information

Product Name	(S)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester
CAS No.	225517-81-7
Molecular Formula	C15H20N2O4
Molecular Weight	292.33 g/mol
Synonyms	Methyl (S)-1-[(benzyloxy)carbonyl]-2-piperazinecarboxylate; (S)-1-Cbz-2-Piperazinecarboxylic Acid Methyl Ester; (S)-1-(Benzyloxycarbonyl)piperazine-2-carboxylic Acid Methyl Ester; (S)-4-(Benzyloxycarbonyl)piperazine-2-carboxylic Acid Methyl Ester; (S)-N-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester; (S)-1-N-Carbobenzyloxy-piperazine-2-carboxylic Acid Methyl Ester; (2S)-1-[(Benzyloxy)carbonyl]piperazine-2-carboxylic Acid Methyl Ester; (S)-1-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER
EINECS	Contact for details

Quality Control

Our (S)-4-n-Cbz-Piperazine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.