Description

Siramesine, also known as Lu-28-179, is a selective σ-2 receptor ligand with significant research interest in the field of neuropharmacology. This compound matters for its potential role in modulating cellular processes related to apoptosis and neuroprotection, making it a valuable tool for advancing neurological and oncological research. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutic agents for central nervous system disorders and cancer.

Application

• Primary pharmacological research on σ-2 receptor function and signaling pathways.
• Investigation of potential neuroprotective agents for neurodegenerative diseases.
• Study of pro-apoptotic mechanisms in cancer cell lines for oncology research.
• Tool compound for in vitro and in vivo models of psychiatric and neurological conditions.
• Reference standard for analytical method development and validation in pharmaceutical quality control.
• Biochemical research exploring the role of sigma receptors in cellular stress responses.

Basic Information

Item	Detail
Product Name	Siramesine, Lu-28-179
CAS No.	224177-60-0
Molecular Formula	C24H32N2O2
Molecular Weight	380.53 g/mol
Synonyms	Lu 28-179; Lu-28179; 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isoindoline-1,4'-piperidine]; Spiro[isoindole-1,4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-; σ-2 receptor ligand Lu 28-179
EINECS	Contact for details

Quality Control

Our Siramesine is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, critical for reliable research outcomes. All batches undergo comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.